Aug 1, 2023 · skin rash. swollen joints. stomach discomfort, upset or pain. tender swollen glands in neck. tremor. unusual excitement, nervousness, restlessness, or irritability. vomiting. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Taking an over-the-counter sleep aid with diphenhydramine once in a while is generally not going to cause problems, other than a possible hangover the next day. Older people, however, can get confused when taking diphenhydramine because it also blocks a brain chemical called acetylcholine, which plays a big role in attention and short-term memory.The short answer seems to be yes. While occasionally taking a Benadryl for sleep probably won’t lead to significant weight gain, chronic use of antihistamines can interfere with weight loss efforts. If you need an antihistamine for frequent allergy symptoms, however, the best choice is Claritin because it does not cross into the brain and has ...Jun 6, 2023 · Benadryl may cause serious side effects including: pounding heartbeats or fluttering in your chest, painful or difficult urination, little or no urination, confusion, lightheadedness, tightness in your neck or jaw, and. uncontrollable movements of your tongue. Get medical help right away, if you have any of the symptoms listed above. Yes, certain side effects are possible after using Benadryl long term. For example, long-term use of Benadryl may cause: an increased risk of dementia; withdrawal symptoms after the drug is stopped* However, keep in mind that doctors typically don’t recommend taking Benadryl as a long-term treatment.While there are cases of misuse and abuse, withdrawal symptoms from Benadryl are rare, even with long term use. Nevertheless, Benadryl has strong anticholinergic effects, and there have been reports of 'anticholinergic withdrawal' in some individuals taking Benadryl for extended periods of time. Potential symptoms include:Side Effects Of Benadryl. Overall, Benadryl is well tolerated and side effects are generally mild in severity. If they do occur, they should subside 4 to 6 hours after dosing, although this can be extended in those with kidney disease and in the elderly. Below, we discuss the most common side effects associated with Benadryl.Side effects of antihistamines that make you drowsy can include: sleepiness (drowsiness) and reduced co-ordination, reaction speed and judgement – do not drive or use machinery after taking these antihistamines. dry mouth. blurred vision. difficulty peeing. Side effects of non-drowsy antihistamines can include: headache. Besides having side effects including drowsiness, confusion, and urinary retention, a new study shows that frequent, long-term use of older antihistamines are associated with an increased risk of ...Side Effects Of Benadryl. Overall, Benadryl is well tolerated and side effects are generally mild in severity. If they do occur, they should subside 4 to 6 hours after dosing, although this can be extended in those with kidney disease and in the elderly. Below, we discuss the most common side effects associated with Benadryl.When corrected based on the number of drugs with anticholinergic effects an individual was taking, the odds ratio for cognitive impairment was 1.46 with a p value of .0181. However, overall the authors conclude that their data did not support the hypothesis that the use of anticholinergic medications increased the risk of alzheimer’s dementia ...Jun 5, 2019 · Addiction and Misuse. Another cause of overdose is an addiction to Diphenhydramine. Patients can become addicted to Benadryl after taking it for an extended period or when it is used for recreational purposes. Side effects of Diphenhydramine overdose often cause long-term damage, which can be fatal to patients ingesting it. Hives. Swelling and inflammation. Redness. Runny nose and eyes. Coughing. Sneezing. Anaphylactic reaction. One of the side effects of Benadryl is drowsiness, which can help to calm anxious dogs ...Diphenhydramine or : Benadryl (diphenhydramine) may cause sedation the next day (due to its long half-life), decreased alertness, diminished cognitive function, delirium, ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. 5k views Reviewed >2 years ago.There is evidence that the use of diphenhydramine among older adults or the elderly may result in serious side effects. This holds true esp. if you are older than age 65. The older a person becomes, the greater the risk of adverse effects. Benadryl is listed as potentially Inappropriate Medication in Older Adults ( also known as Beers criteria)Potential Kidney Risks. Yes, long-term use of Benadryl can put strain on the kidneys, as it can build up in the system. This can cause toxicity and potentially lead to kidney damage. It's important to be aware of the potential side effects of long-term use and to consult a doctor if any symptoms arise.The most common side effect is drowsiness, causing mild disorientation or dementia. An elderly person may fall asleep during normal activities. This sedating effect can cause unsteadiness. A person over 60 should get up slowly from a sitting or prone position to avoid fainting. If you take an anti-anxiety drug, it is not advisable to use ...Jul 9, 2020 · This video examines the question and remark: Benadryl long term side effects! I WISH I had KNOWN! Benadryl is a common OTC medication and is also known as D... Answer (1 of 2): Here is one long term study: “These drugs are called anticholinergics, among them the first-generation antihistamines that are now marketed as sleep aids.Aug 15, 2023 · It can sometimes cause a decrease in memory, confusion, and thinking issues. These side effects are more common in elders. In addition, taking Benadryl long-term might increase the risk of dementia. People aged> 65 who took medications such as Benadryl daily for over three years had an increased risk of dementia. The symptoms you have noticed are very likely the result of long-term heavy antihistamine use. Antihistamines tend to dry up the nose, which is why they are so effective in humans with allergic rhinitis, but the way they do that is by making the secretions thicker. In dogs, we are not worried much about a runny nose, but we are concerned about ...Sep 4, 2023 · Impaired concentration. Memory difficulties. Anxiety. Stomach disturbances. Nausea and vomiting. A dry mouth. Constipation. Liver problems, etc. In certain people, a paradoxical reaction to diphenhydramine is possible, meaning that the drug causes different symptoms than the intended ones. • Common side effects of montelukast include upper respiratory infection, fever, headache, sore throat, cough, stomach pain, diarrhea, earache or ear infection, flu, runny nose, and sinus infection. Official answer. Diphenhydramine can be used as a short-term sleep aid to help ease occasional sleep problems. Older adults, children under age 16 and pregnant women should avoid taking diphenhydramine, as the risks to these groups may outweigh the benefits. Diphenhydramine should not be taken as a treatment for chronic insomnia. Yes, certain side effects are possible after using Benadryl long term. For example, long-term use of Benadryl may cause: an increased risk of dementia; withdrawal symptoms after the drug is stopped* However, keep in mind that doctors typically don’t recommend taking Benadryl as a long-term treatment.The short answer seems to be yes. While occasionally taking a Benadryl for sleep probably won’t lead to significant weight gain, chronic use of antihistamines can interfere with weight loss efforts. If you need an antihistamine for frequent allergy symptoms, however, the best choice is Claritin because it does not cross into the brain and has ...Jan 10, 2023 · hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ... Diphenhydramine or : Benadryl (diphenhydramine) may cause sedation the next day (due to its long half-life), decreased alertness, diminished cognitive function, delirium, ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. 5k views Reviewed >2 years ago. Dizziness Nausea or vomiting Loss of appetite Constipation Increased chest congestion Headache Excitability (especially in children) Nervousness Benadryl can impair mental and motor functioning, as well as your performance at work or school. It can also impair a person’s ability to operate a motor vehicle or other potentially dangerous equipment.Mar 21, 2023 · There is very little scientific research about the long-term effects of Benadryl. Some side effects that may occur with long-term use include: constipation; blurred vision Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect. 5. Tips. Benadryl may be taken with or without food. Take exactly as directed.Jun 14, 2023 · The symptoms you have noticed are very likely the result of long-term heavy antihistamine use. Antihistamines tend to dry up the nose, which is why they are so effective in humans with allergic rhinitis, but the way they do that is by making the secretions thicker. In dogs, we are not worried much about a runny nose, but we are concerned about ... Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia - including Alzheimer’s - says large study.Jul 9, 2020 · This video examines the question and remark: Benadryl long term side effects! I WISH I had KNOWN! Benadryl is a common OTC medication and is also known as D... and readily penetrates the blood-brain-barrier. Thus side effects such as grogginess, drowsiness, and memory loss are common. Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson’s disease patients. Potential harm to the brain: Long-term anticholinergic use has been associated with increasedThe main long-term side effects of Plaquenil are eye-related. ... To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine ...Apr 8, 2022 · People who take too much Benadryl start to experience many of the medication’s side effects. These can include mild symptoms, such as dry mouth, constipation, and tiredness. Usually, the more Benadryl a person takes, the worse these side effects become. In more severe Benadryl overdose cases, symptoms like seizures, irregular heartbeats, and ... Benadryl Addiction Side Effects. Despite having numerous benefits in the medical world, Benadryl has its share of negative side effects when abused. Some effects are short term whereas others can last a lifetime. A user can either encounter psychological effects, physical effects, or both. Some of the physical effects to watch out for include ...Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth. Fixed combination loratadine (the active ingredient contained in Claritin) pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.In the drug realm, antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), cetirizine (Zyrtec), and loratadine (Claritin) can help with a stuffy nose are safe for the heart. Nasal sprays deliver a decongestant right where you need it. In theory, this should minimize cardiovascular effects.Diphenhydramine (Benadryl) is a common over-the-counter allergy medication. It’s part of a class of drugs called anticholinergics that research has linked to dementia in older people.Apr 24, 2023 · Long-term use may also lead to harmful side effects. The inability to fall or stay asleep can have a significant, negative impact on your mood, productivity, and overall health. Insomnia can also ... Jan 10, 2023 · hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ... Long-term use may also lead to harmful side effects. The inability to fall or stay asleep can have a significant, negative impact on your mood, productivity, and overall health. Insomnia can also ...Diphenhydramine or : Benadryl (diphenhydramine) may cause sedation the next day (due to its long half-life), decreased alertness, diminished cognitive function, delirium, ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. 5k views Reviewed >2 years ago.The main long-term side effects of Plaquenil are eye-related. ... To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine ...This video examines the question and remark: Benadryl long term side effects! I WISH I had KNOWN! Benadryl is a common OTC medication and is also known as D...Diphenhydramine or : Benadryl (diphenhydramine) may cause sedation the next day (due to its long half-life), decreased alertness, diminished cognitive function, delirium, ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. 5k views Reviewed >2 years ago.• Common side effects of montelukast include upper respiratory infection, fever, headache, sore throat, cough, stomach pain, diarrhea, earache or ear infection, flu, runny nose, and sinus infection. Diphenhydramine is a common ingredient in sleeping aids; it is also used to treat allergies. While effective, the risk of serious diphenhydramine side effects—including confusion, dizziness, urinary retention, and liver or kidney issues—is increased in people age 65 and older.Warnings What to ask your doctor Q&A Benadryl (diphenhydramine) is used for allergies and allergic reactions, as well as common cold symptoms. Benadryl can cause mild or serious side...Yes, certain side effects may be possible with long-term use of Benadryl. However, doctors usually don’t recommend Benadryl for long-term use. Instead, they typically advise short-term use of the drug to ease certain symptoms. The drug’s label information* for Benadryl does not specify any long-term side effects for this drug.Diphenhydramine is a type of medicine called an antihistamine. It is used in some allergy and sleep medicines. Overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This article is for information only. DO NOT use it to treat or manage an actual overdose. Common Benadryl (diphenhydramine) side effects include drowsiness, dizziness, and blurry vision. Dry mouth and constipation are common, as well. Serious Benadryl side effects include a greater risk of falls — especially if you are an older adult — and potential long-term memory problems.Answer From Eric J. Olson, M.D. It's unlikely you'll become dependent on zolpidem (Ambien). Ambien and similar sleep medications can be effective, and they're much less likely to be habit-forming than some other drugs sometimes prescribed for sleep problems — for example, benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan) or ...Diphenhydramine is a type of medicine called an antihistamine. It is used in some allergy and sleep medicines. Overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This article is for information only. DO NOT use it to treat or manage an actual overdose. A 2017 study revealed that 10% of adults aged 18-45 use OTC sleep aids while 17.5% of people 65 years and older do. Most over-the-counter options are considered safe when used occasionally—as long as the medication is compatible with any medical conditions you have and other medications you take. But when taken night after night, trouble can ...It can sometimes cause a decrease in memory, confusion, and thinking issues. These side effects are more common in elders. In addition, taking Benadryl long-term might increase the risk of dementia. People aged> 65 who took medications such as Benadryl daily for over three years had an increased risk of dementia.Apr 9, 2020 · Diphenhydramine, brand name Benadryl ®, is one of the oldest and most frequently used over-the-counter medications for children. However, many better options are now widely available, all of which are faster acting, longer lasting, with less side effects. Antihistamines counteract the effect of histamine throughout the body, and treat a range ... May 25, 2023 · Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Not able to pass urine or change in how much urine is passed. A very bad skin reaction ( Stevens-Johnson syndrome / toxic epidermal necrolysis) may happen. Sep 4, 2023 · Impaired concentration. Memory difficulties. Anxiety. Stomach disturbances. Nausea and vomiting. A dry mouth. Constipation. Liver problems, etc. In certain people, a paradoxical reaction to diphenhydramine is possible, meaning that the drug causes different symptoms than the intended ones. The Major Antihistamine Effects of Diphenhydramine Prevents Histamine-Mediated: constriction of respiratory smooth muscle. rapid vasodilation in blood vessels. increased capillary permeability and subsequent edema. sensations of itching, pain, and “flare” formation. increase in heart rate and strength of contraction.Applies to diphenhydramine: compounding powder, injectable solution, oral capsule, oral disintegrating strip, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating. General The most commonly reported side effects included somnolence, dizziness, and incoordination.Dec 1, 2022 · Section snippets Sedation. The sedation associated with diphenhydramine is one of the most acknowledged effects of this medication. Indeed, it is frequently used as a medication to treat insomnia. 3 The sedative effect of diphenhydramine is related to its easy penetration of the blood-brain barrier. 4 In the brain, diphenhydramine interferes with H 1 receptors, which causes drowsiness and ... Apr 9, 2020 · Diphenhydramine, brand name Benadryl ®, is one of the oldest and most frequently used over-the-counter medications for children. However, many better options are now widely available, all of which are faster acting, longer lasting, with less side effects. Antihistamines counteract the effect of histamine throughout the body, and treat a range ... Jun 28, 2021 · Experts say skip antihistamines. Dana Benson. 713-798-8267. Houston, TX - Jun 28, 2021. Share this article. For people who take an antihistamine such as Benadryl for a cold or allergies, drowsiness is often a welcome side effect. But a Baylor College of Medicine sleep expert cautions against turning to this type of medication as a sleep aid. Answer From Eric J. Olson, M.D. It's unlikely you'll become dependent on zolpidem (Ambien). Ambien and similar sleep medications can be effective, and they're much less likely to be habit-forming than some other drugs sometimes prescribed for sleep problems — for example, benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan) or ...Warnings What to ask your doctor Q&A Benadryl (diphenhydramine) is used for allergies and allergic reactions, as well as common cold symptoms. Benadryl can cause mild or serious side...Nov 24, 2022 · But it has quite a long list of possible side effects. In fact, the Canadian Society of Allergy and Clinical Immunology has given serious warnings about them, even for people. The organization issued a 2019 position statement about Benadryl. They advised against the drug because of the high risk of side effects and overdose. They said the drug ... Anxiety. Asthma. Car Sickness. Insomnia. Motion sickness. Reactions to Vaccines. Because one of the common side effect of Benadryl in dogs is drowsiness, your vet may use it to alleviate dog anxiety, particularly associated with traveling and motion sickness that may occur during plane rides or car trips.Jun 5, 2019 · Addiction and Misuse. Another cause of overdose is an addiction to Diphenhydramine. Patients can become addicted to Benadryl after taking it for an extended period or when it is used for recreational purposes. Side effects of Diphenhydramine overdose often cause long-term damage, which can be fatal to patients ingesting it. Diphenhydramine or : Benadryl (diphenhydramine) may cause sedation the next day (due to its long half-life), decreased alertness, diminished cognitive function, delirium, ... Read More. Created for people with ongoing healthcare needs but benefits everyone. Learn how we can help. 5k views Reviewed >2 years ago.Yeah, look at r/dph.Datura is even worse. It's like dph, but way more likely to kill you or make you go blind. Shadow people and spiders and having full conversations with people who don't exist usually only happens in the 400+ category. Between 150mg and there, it's usually just having to piss but being unable to, dysphoria/fear, beLong-term use may also lead to harmful side effects. The inability to fall or stay asleep can have a significant, negative impact on your mood, productivity, and overall health. Insomnia can also ...One Benadryl per night seems to be enough to keep the ears dry & the resulting nausea at bay. I must admit that I'm not sure this is still even a problem for me. The last time I stopped to see if I still needed it was about 2 years ago. After 3 days, the dizziness/nausea/inner ear issues came back, so I promptly started taking the nightly ...Anxiety. Asthma. Car Sickness. Insomnia. Motion sickness. Reactions to Vaccines. Because one of the common side effect of Benadryl in dogs is drowsiness, your vet may use it to alleviate dog anxiety, particularly associated with traveling and motion sickness that may occur during plane rides or car trips.Jun 15, 2016 · IV administration of 50 mg of DPH resulted in immediate improvement of tremor, rigidity, tachycardia, and eye versions. The patient was started on oral DPH 50 mg 4 times a day and the dose was reduced by 25% every 3 days. Oral clonidine 0.1 mg 3 times a day and a weekly 0.1 mg transdermal patch was added to mitigate sympathetic side effects. General The most commonly reported side effects included somnolence, dizziness, and incoordination. [ Ref] Nervous system Common (1% to 10%): Sedation/somnolence/sleepiness, drowsiness, unsteadiness, dizziness, headache, attention disturbance Rare (0.01% to 0.1%): Extrapyramidal effects, tremor, convulsionsNov 15, 2019 · Central side effects. Since these actions are disrupted by sedating antihistamines, these drugs produce sedation, drowsiness, tiredness, lack of concentration, difficulty in learning and memory ... Benadryl Addiction Side Effects. Despite having numerous benefits in the medical world, Benadryl has its share of negative side effects when abused. Some effects are short term whereas others can last a lifetime. A user can either encounter psychological effects, physical effects, or both. Some of the physical effects to watch out for include ...Yeah, look at r/dph.Datura is even worse. It's like dph, but way more likely to kill you or make you go blind. Shadow people and spiders and having full conversations with people who don't exist usually only happens in the 400+ category. Between 150mg and there, it's usually just having to piss but being unable to, dysphoria/fear, be Applies to diphenhydramine: compounding powder, injectable solution, oral capsule, oral disintegrating strip, oral liquid, oral tablet, oral tablet chewable, oral tablet disintegrating. General The most commonly reported side effects included somnolence, dizziness, and incoordination.Hives. Swelling and inflammation. Redness. Runny nose and eyes. Coughing. Sneezing. Anaphylactic reaction. One of the side effects of Benadryl is drowsiness, which can help to calm anxious dogs ...and readily penetrates the blood-brain-barrier. Thus side effects such as grogginess, drowsiness, and memory loss are common. Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson’s disease patients. Potential harm to the brain: Long-term anticholinergic use has been associated with increased Some dosage forms listed on this page may not apply to the brand name Benadryl Allergy. Summary. More frequent side effects include: sedated state and thickening of bronchial secretions. Continue reading for a comprehensive list of adverse effects. Applies to diphenhydramine: oral capsules and tablets, parenteral injection. Side effects include:
May 25, 2023 · Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Not able to pass urine or change in how much urine is passed. A very bad skin reaction ( Stevens-Johnson syndrome / toxic epidermal necrolysis) may happen. . Soe 881 jav
May 17, 2018 · Answer From Eric J. Olson, M.D. It's unlikely you'll become dependent on zolpidem (Ambien). Ambien and similar sleep medications can be effective, and they're much less likely to be habit-forming than some other drugs sometimes prescribed for sleep problems — for example, benzodiazepines, such as alprazolam (Xanax), lorazepam (Ativan) or ... Answer (1 of 2): Here is one long term study: “These drugs are called anticholinergics, among them the first-generation antihistamines that are now marketed as sleep aids.Nov 15, 2017 · Asthma. Car Sickness. Insomnia. Motion sickness. Reactions to Vaccines. Because one of the common side effect of Benadryl in dogs is drowsiness, your vet may use it to alleviate dog anxiety, particularly associated with traveling and motion sickness that may occur during plane rides or car trips. • Common side effects of montelukast include upper respiratory infection, fever, headache, sore throat, cough, stomach pain, diarrhea, earache or ear infection, flu, runny nose, and sinus infection.Effects of Long-Term Diphenhydramine Use The information regarding the effects of prolonged Benadryl use is once again not known, as prospective studies analyzing its prolonged use do not exist. There are some exceptions to the above statement, however, the following are related to the long-term use of any antihistamine medication and ...Diphenhydramine is contraindicated in premature infants and neonates, as well as people who are breastfeeding. It is a pregnancy Category B drug. Diphenhydramine has additive effects with alcohol and other CNS depressants. Monoamine oxidase inhibitors prolong and intensify the anticholinergic effect of antihistamines. OverdoseBenadryl and Depression. Although there is no direct effect of Benadryl on depression, regular and daily use of Benadryl does result in severe depression in the individual. It is believed to be helpful only for the short term, however, long term use of Benadryl results in certain depressive symptoms in the individual.Diphenhydramine blocks the effects of histamine in your brain and this reduces symptoms. It enters the brain in large quantities and this can make you feel drowsy. Diphenhydramine also blocks the effects of another chemical called acetylcholine. This can help a cough or runny nose but can also cause side effects such as a dry mouth and dry nose. Jul 9, 2015 · Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia - including Alzheimer’s - says large study. Some dosage forms listed on this page may not apply to the brand name Benadryl Allergy. Summary. More frequent side effects include: sedated state and thickening of bronchial secretions. Continue reading for a comprehensive list of adverse effects. Applies to diphenhydramine: oral capsules and tablets, parenteral injection. Side effects include:May 22, 2013 · When corrected based on the number of drugs with anticholinergic effects an individual was taking, the odds ratio for cognitive impairment was 1.46 with a p value of .0181. However, overall the authors conclude that their data did not support the hypothesis that the use of anticholinergic medications increased the risk of alzheimer’s dementia ... Sep 14, 2022 · Benadryl helps reduce the effects of natural chemicals in the body called histamines. It is used to treat the side effects of an allergic reaction, including: Benadryl can be taken to relieve the symptoms of hayfever (seasonal allergies) and motion sickness. It can also be taken to induce sleep and treat certain symptoms of Parkinson's disease. Extrapyramidal side effects (EPS), commonly referred to as drug-induced movement disorders are among the most common adverse drug effects patients experience from dopamine-receptor blocking agents. It was first described in 1952 after chlorpromazine-induced symptoms resembling Parkinson disease.[1] A variety of movement phenotypes has since been described along the EPS spectrum, including ...Long term use of some antihistamines may increase your risk of dementia. Diphenhydramine (Benadryl®) blocks the effects of a neurotransmitter called acetylcholine. This neurotransmitter is vital for memory and learning. Diphenhydramine increased the risk of dementia by 54% in one 3,000 patient study followed for seven years. .